The other camp insists that the best way to use a natural 1 is to create a humorous, yet non-lethal, failure. This is where you get the search checks that have you finding your toes, spell failure that results in ballerina platypuses, and dragons face planting into turnip gardens. It may ruin the mood of your game completely, but darn is it ever fun.
Yes, I'm biased. No, I don't care.